leprosy bacillus - PMC

Chyntia Carolina Díaz Acosta, André Alves Dias, Thabatta Leal Silveira Andrezo Rosa, Leonardo Ribeiro Batista-Silva, Patricia Sammarco Rosa, Thiago Gomes Toledo-Pinto, Fabrício da Mota Ramalho Costa, Flávio Alves Lara, Luciana Silva Rodrigues, Katherine Antunes Mattos, Euzenir Nunes Sarno, Patrícia Torres Bozza, Christophe Guilhot, Márcia de Berrêdo-Pinho, Maria Cristina Vidal Pessolani

PLoS Pathog. 2018 Jul; 14(7): e1007151. Published online 2018 Jul 6. doi: 10.1371/journal.ppat.1007151

PMCID:: PMC6056075

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In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae

Anouk van Hooij, Annemieke Geluk

Immunol Rev. 2021 May; 301(1): 175–192. Published online 2021 Mar 11. doi: 10.1111/imr.12966

PMCID:: PMC8251784

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Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

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PMCID:: PMC9201476

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Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review

Thomas Hambridge, Shri Lak Nanjan Chandran, Annemieke Geluk, Paul Saunderson, Jan Hendrik Richardus

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Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

Andrej Benjak, Charlotte Avanzi, Pushpendra Singh, Chloé Loiseau, Selfu Girma, Philippe Busso, Amanda N. Brum Fontes, Yuji Miyamoto, Masako Namisato, Kidist Bobosha, Claudio G. Salgado, Moisés B. da Silva, Raquel C. Bouth, Marco A. C. Frade, Fred Bernardes Filho, Josafá G. Barreto, José A. C. Nery, Samira Bührer-Sékula, Andréanne Lupien, Abdul R. Al-Samie, Yasin Al-Qubati, Abdul S. Alkubati, Gisela Bretzel, Lucio Vera-Cabrera, Fatoumata Sakho, Christian R. Johnson, Mamoudou Kodio, Abdoulaye Fomba, Samba O. Sow, Moussa Gado, Ousmane Konaté, Mariane M. A. Stefani, Gerson O. Penna, Philip N. Suffys, Euzenir Nunes Sarno, Milton O. Moraes, Patricia S. Rosa, Ida M. F. Dias Baptista, John S. Spencer, Abraham Aseffa, Masanori Matsuoka, Masanori Kai, Stewart T. Cole

Nat Commun. 2018; 9: 352. Published online 2018 Jan 24. doi: 10.1038/s41467-017-02576-z

PMCID:: PMC5783932

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GSMN-ML- a genome scale metabolic network reconstruction of the obligate human pathogen Mycobacterium leprae

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PMCID:: PMC7365477

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Mycobacterium leprae and host immune transcriptomic signatures for reactional states in leprosy

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PMCID:: PMC10083373

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New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission

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Version 1. F1000Res. 2020; 9: F1000 Faculty Rev-70. Published online 2020 Jan 31. doi: 10.12688/f1000research.21383.1

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Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

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Mycobacterium leprae Activates Toll-Like Receptor-4 Signaling and Expression on Macrophages Depending on Previous Bacillus Calmette-Guerin Vaccination

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Reservoirs and transmission routes of leprosy; A systematic review

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PMCID:: PMC7205316

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Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins

Itu Singh, Asha Ram Yadav, Keshar Kunja Mohanty, Kiran Katoch, Prashant Sharma, Vinay Kumar Pathak, Deepa Bisht, Umesh D. Gupta, Utpal Sengupta

Front Immunol. 2018; 9: 642. Published online 2018 Apr 3. doi: 10.3389/fimmu.2018.00642

PMCID:: PMC5891605

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TLR-9 Plays a Role in Mycobacterium leprae-Induced Innate Immune Activation of A549 Alveolar Epithelial Cells

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PMCID:: PMC8397448

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Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review

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PMCID:: PMC8428563

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Genomic Characterization of Mycobacterium leprae to Explore Transmission Patterns Identifies New Subtype in Bangladesh

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Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia

Marcela Romero-Montoya, Juan Camilo Beltran-Alzate, Nora Cardona-Castro

PLoS Negl Trop Dis. 2017 Jan; 11(1): e0005325. Published online 2017 Jan 23. doi: 10.1371/journal.pntd.0005325

PMCID:: PMC5289623

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Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens

Fernanda Marques de Carvalho, Luciana Silva Rodrigues, Nádia Cristina Duppre, Iris Maria Peixoto Alvim, Marcelo Ribeiro-Alves, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Maria Cristina Vidal Pessolani, Geraldo Moura Batista Pereira

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PMCID:: PMC5432189

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Mycobacterium leprae Transcriptome During In Vivo Growth and Ex Vivo Stationary Phases

Olabisi Ojo, Diana L. Williams, Linda B. Adams, Ramanuj Lahiri

Front Cell Infect Microbiol. 2021; 11: 817221. Published online 2022 Jan 12. doi: 10.3389/fcimb.2021.817221

PMCID:: PMC8790229

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Figure 3

Photomicrograph of a skin biopsy. (A) Immunoreactivity for IL-12 in a case of MB leprosy before the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (B) Immunoreactivity for IL-12 in a case of MB leprosy after the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (C) Immunoreactivity for TGF-β in a case of MB leprosy before the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (D) Immunoreactivity for TGF-β in a case of MB leprosy after the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (E) Immunoreactivity for TNF-α in a case of MB leprosy before the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (F) Immunoreactivity for TNF-α in a case of MB leprosy after the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (G) Immunoreactivity for TNF-α in a case of PB leprosy before the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (H) Immunoreactivity for TNF-α in a case of PB leprosy after the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100).
Abbreviations: IL, interleukin; MB, multibacillary; BCG-id, bacillus Calmette–Guérin – intradermal; TGF-β, transforming growth factor beta; TNF-α, tumor necrosis factor-alpha.

Clinical and immunological evaluation after BCG-id vaccine in leprosy patients in a 5-year follow-up study

J Inflamm Res. 2012;5:125-135.
Figure 2

Photomicrograph of a skin biopsy. (A) Infiltrate of histiocytes surrounded by lymphocytes in the dermis in a case of MB leprosy before the BCG-id (HE, ×100). (B) Tendency towards granuloma formation in a case of MB leprosy after the BCG-id (HE, ×100). (C) Immunoreactivity for INFγ in a case of MB leprosy before the BCG-id (NovoLink staining with hematoxylin counterstaining, ×50). (D) Immunoreactivity for INFγ in a case of MB leprosy after the BCG-id (NovoLink staining with hematoxylin counterstaining, ×50). (E) Immunoreactivity for IL-1 in a case of MB leprosy before the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (F) Immunoreactivity for IL-1 in a case of MB leprosy after the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (G) Immunoreactivity for IL-10 in a case of MB leprosy before the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100). (H) Immunoreactivity for IL-10 in a case of MB leprosy after the BCG-id (NovoLink staining with hematoxylin counterstaining, ×100).
Abbreviations: MB, multibacillary; BCG-id, bacillus Calmette–Guérin – intradermal; HE, hematoxilin eosin; INF-γ, interferon-gamma; IL, interleukin.

Clinical and immunological evaluation after BCG-id vaccine in leprosy patients in a 5-year follow-up study

J Inflamm Res. 2012;5:125-135.
Figure 1

Histopathological features of leprosy lesions in I leprosy, TT leprosy, and LL showing focal lymphocytic inflammatory infiltrates that were distributed around cutaneous appendages, nerve fibers, and vessels in I leprosy.
Notes: TT leprosy shows granulomas consisting of clustered epithelioid cells, sometimes surrounded by lymphocytic halos. In LL, an inflammatory infiltrate consisting of histiocytes and plasma cells along the entire upper dermis was present around the nerves and blood vessels and around the bacillus stained by Ziehl– Neelsen stain (200× magnification). (A) I leprosy (arrows indicate a lymphocytes), (B) TT leprosy (arrows indicate epithelial cells), (C) LL (arrows indicate histocytes), and (D) Ziehl–Neelsen staining (arrows indicate bacillus of M. leprae).
Abbreviations: I, indeterminate; LL, lepromatous leprosy; TT, tuberculoid.

The inflammasome in leprosy skin lesions: an immunohistochemical evaluation

Infect Drug Resist. 2018;11:2231-2240.
Figure 1

Bacillus of Calmette and Guérin (BCG) vaccination coverage estimates and reported leprosy detection rates, Paraguay, 1980–2017. Source from: World Health Organization. Global health observatory data. Leprosy - number of reported cases by country [].

Bacillus of Calmette and Guérin (BCG) and the risk of leprosy in Ciudad del Este, Paraguay, 2016–2017

Epidemiol Health. 2021;43:e2021060.